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Restoring the hair lost due to hereditary factors is the dream of many hair loss sufferers. Until not too long ago, the only effective and authentic-looking methods of reversing hair loss were non-surgical cover-ups. It was only with the advent of follicular unit transplantation and the discovery of the true cause of baldness – the harmful effects of dihydrotestosterone (DHT) on our hair follicles – that the hair-loss sufferer’s chances of reversing hair loss naturally have greatly improved.
The three best weapons in the fight against hair loss today are the two FDA-approved medicinal drugs – finasteride (Propecia) and minoxidil (Rogaine) and hair surgery, the follicular unit transplantation and, especially, the follicular unit extraction technique. However, no ultimate cure exists yet as each of the three aforementioned hair restoration methods has its limitations. Minoxidil and finasteride work well only in the vertex area of the scalp, and finasteride cannot be used by women. Hair surgery is suitable only for people who have sufficient hair density in the donor area, and many women, who typically suffer from diffuse thinning, do not make good candidates for hair transplantation.
Therefore, scientists around the world are relentlessly searching for new approaches to treating baldness. There are presently several promising drugs and new techniques under development listed below but progress seems to have slowed down recently due to the global financial crisis, as some R&D projects are finding it increasingly difficult to raise financing to further their research.
The greatest progress has been achieved on dutasteride. Dutasteride is an antiandrogen, in its chemical structure and mode of action it is similar to finasteride. It is used to treat benign prostatic hyperplasia and since it is a dual 5-alpha reductase inhibitor, it should be a more potent DHT blocker than finasteride. Therefore, it is thought to be more effective in treating hair loss, especially in the frontal area of the scalp. Dutasteride completed Phase III clinical testing this year and the study results are expected to be published soon.
NEOSH101 was originally developed by the US medical research firm Neosil and was until recently undergoing phase IIb clinical testing. At the end of 2008, Neosil was acquired by Peplin, Inc., a development stage specialty pharmaceuticals company and since then no information on the further progress of the clinical trials has been released. In previous clinical trials, NEOSH101 was proven to be a more powerful and faster-acting, hair growth stimulant than minoxidil and it only needs applying once daily. Though significantly improving the current hair-loss treatment options, NEOSH101 is not going to become the ultimate cure for baldness. The clinical trials seem to be advancing slower than most hair-loss sufferers would like and, hence, do not hold your breath waiting for it to hit the market anytime soon.
Another promising development area is the telomerase research. Telomerase is an enzyme that is able to put natural caps on telomeres and thus protect them from shortening. Telomerase thereby maintains the genomic integrity. Shortened telomeres are associated with causing premature aging processes. However, the uncontrolled activation of telomerase can trigger cancer. Cancer research is the main focus of the telomerase studies but scientists are also looking for other applications, such as anti-aging drugs and drugs against baldness and grey hair. Telomerase research could really change the world of medicine but its commercial application might be a good 15 years away.
Hair multiplication, often called hair regeneration or hair cloning, is the next hopeful treatment option being developed. This technique involves extracting hair follicles from the back of the patient’s scalp, culturing and multiplying them and injecting the newly-grown hair cells into the bald scalp area. The UK healthcare firm Intercytex appears to be the frontrunner in hair multiplication research. Intercytex has already completed phase II clinical study of ICX-TRC (a suspension of a patient’s own dermal papilla cells). The main benefit of hair multiplication would be solving the shortage of donor hair that is the main limiting factor in hair transplant surgery. However, Intercytex is currently facing financial difficulties and after failing to find an investor, it will have to continue operating on its own. Aderans, the main competitor of Intercytex, has also recently launched a Phase II clinical study on cell-based hair regeneration for men and women.
Generating new hair follicles in hair-free skin wounds is a completely new approach to regrowing hair. It was discovered accidentally when wounded skin in mice started producing new hair. This technology is currently being developed by the US medical device company, Follica, which has licensed this technology from the University of Pennsylvania. Though this method may sound weird, it is said to only use common instruments and drugs that have already been medically approved and thus it might not take too long for it to become available.
This list of the undergoing projects in the area of hair-loss research includes the most promising lines of development but it is not exhaustive. However, none of the new therapies, with the exception of dutasteride’s application for treating hair loss in men, is expected to hit the market before 2013 and the immediate future of hair restoration lies in improving the surgical techniques, increasing the yields of the follicular unit extraction method and making it more affordable to a larger portion of the population.
About the Author
For more information on novel as well as existing treatments for hair loss and grey hair please visit the author’s website dedicated to educating the public on treating genetically-determined hair conditions and do not be ashamed to write a review on the hair treatments and therapies you have used, in order to help others assess the potency of available products.
Article Source: Content for Reprint
At the moment, there are only two medicinal treatments that have been approved by the FDA (Food and Drug Administration) in the US for treating hair loss – topical minoxidil (trade name Rogaine) and oral finasteride (Propecia). Topical minoxidil is suitable for both sexes, whereas finasteride can only be prescribed to male patients. Minoxidil is a vasodilator, originally used to treat high blood pressure, which was later found to stimulate hair growth when applied topically to the scalp. Finasteride is an antiandrogen that was first used to treat benign prostatic hyperplasia (BPH), also known as prostate enlargement. It acts by inhibiting conversion of the male hormone testosterone to the follicle-harming dihydrotestosterone (DHT). The discovery of finasteride’s positive effects on hair growth led to finding the true cause of hereditary baldness, which is the harmful attacks of DHT on our hair follicles. Since making this discovery, a quest for other alternative DHT blockers has begun, especially amongst antiandrogen drugs and herbs that have, in the past, been used to treat urinary problems.
Dutasteride (trade name Avodart) is an antiandrogen drug similar to finasteride in its chemical structure and mode of action and has been studied extensively for treating hair loss. It has recently completed phase III clinical testing for efficacy and safety in the treatment of male pattern baldness and the study results are pending. Like finasteride it is also used for treating BPH. Dutasteride is believed by many to be a more powerful hair loss drug than finasteride but also with more severe side effects.
Flutamide (trade name Eulexin) is a very strong antiandrogen used to treat prostate cancer. It works by binding to the androgen receptors and thus competing with DHT. Oral use of flutamide can cause serious side effects but it is believed that topical applications might have less adverse side effects and could be, in the future, used to treat hereditary hair loss. More research is needed to verify such claims.
Spironolactone (trade name Aldactone) is another antiandrogen that works by binding to androgen receptors, competing with DHT. It is used in women to treat acne, hair loss and excess body hair and although there are some generic topical applications for the treatment of male pattern baldness which contain spironolactone, it has never been approved to treat hair loss in men and should be avoided. For women, spironolactone can be considered as a reasonable alternative to the men’s best hair-loss pill, finasteride, which cannot be used in women.
As has been mentioned earlier, following the discovery of DHT attacks on hair follicles being the true cause of hereditary baldness, herbalists started looking for possible natural alternatives to finasteride among plants that have been traditionally used to treat urinary problems and, more specifically, enlarged prostates.
Saw palmetto has been used for decades to treat prostate enlargement and it is one of the few plants used in natural remedies that have been subjected to some sort of scientific research in regards to their potential for treating BPH. Its supporters assume that it works by inhibiting the conversion of testosterone into prostate and follicle-harming DHT but no study has yet confirmed this assumption. No clinical research has ever been conducted on saw palmetto’s effects on hair loss. Despite that, saw palmetto is widely used by thousands of hair loss sufferers around the world as a safe natural alternative to finasteride.
Extract from the bark of the evergreen tree pygeum africanum is another popular herbal ingredient found in natural hair-loss treatments and many herbalists believe it is more potent in treating hair loss than saw palmetto. Its rise to fame also comes from the general assumption that this plant, thought to be beneficial for treating prostate enlargement, must be also effective in treating hair loss. Pygeum africanum has been less well studied than saw palmetto and it has never been used in any clinical hair-loss study.
The third most popular herbal ingredient used in natural hair-loss cures is nettle root extract. This herbal drug is derived from the root of the stinging nettle, a popular healing plant found in temperate and subtropical zones of the northern hemisphere. Its use in natural hair-loss remedies also stems from the fact that it is supposed to help shrink enlarged prostates and is thus believed to inhibit the conversion of testosterone to DHT. Like the two aforementioned herbal extracts, nettle has never been used in any clinical hair-loss study.
This list of hair-loss drugs and herbal extracts that are believed to mimic the actions of finasteride, the only approved pill for hair loss, is not exhaustive. There are many other ingredients, mostly of natural origin, that claim the ability to block DHT and thus reverse hair loss. However, no clinical proof exists that any herb contained in the natural remedies promotes new hair growth. Whether you decide to try a commercial herbal remedy or just one or two herbs on their own, keep in mind that, besides there being no guarantee of their effectiveness, no daily dosage has been established and side effects might occur, despite the general belief that herbal hair-loss remedies are safe and free of them. In addition, it is not advised to try any of the aforementioned medicinal substitutes to finasteride without first consulting your doctor.
About the Author
For more information on the existing hair loss treatments and methods of covering gray hair, please visit the author’s website dedicated to educating the public on treating hair loss and premature grey hair and use it to share your own experiences with the hair loss or grey hair products you have used.
Article Source: Content for Reprint
Concealing bald spots is for many patients affected with baldness the only existing option to regain the appearance of a full head of hair, as hair regrowth treatments only work for some hair loss conditions. Non-surgical hair replacement is another term used for covering bald spots by non-surgical means. The two main techniques of non-surgical hair replacement today involve the use of hair systems and hair loss concealers. Various types of hair systems exist, such as full wigs, hairpieces, toupees, hair extensions and weaves. They can all look very authentic and have been used for centuries to cover bald areas. However, their main weaknesses are high maintenance costs and, in many situations, the discomfort of wearing them.
Concealers are a relatively new invention, designed to overcome the difficulties associated with wearing and maintaining wigs, but many people think they are not capable of withstanding adverse external conditions and appear unnatural. This no longer seems to be true, as many of them have greatly improved recently, both in terms of their authentic appearance and their resistance to external influences. It pays to understand how different types of hair replacement products work, in order to estimate their suitability for your current condition and compatibility with your lifestyle.
HAIR SYSTEMS
As for hair systems, there are a number of factors determining the user experience, as well as their price, such as the type of hair, the technology used to make the wig, the foundation of the hair system and how it is attached to the scalp. As far as the type of hair goes, it can be artificial or natural. The latter can be of animal or human origin. Human hair requires more care than artificial hair but it looks more authentic, lasts longer and is more comfortable to wear. Its downside is its higher cost and the fact that it can lose its colour when exposed to direct sun for long hours, or break, as normal human hair does. Secondly, hair systems can be hand-tied or machine-tied. Hand-tied wigs happen to be the more expensive alternative and the more authentic-looking solution. In addition, the foundation of a hair system can be either a polymer or a mesh. The polymer foundation is the more affordable, though less comfortable, option but it lasts longer.
The method of fixing a wig to your scalp and blending it with your existing hair is an extremely important factor. The semi-permanently attached hair systems are either glued to your scalp or woven into your existing hair and can only be removed in a hair salon, once every five weeks for cleaning. The temporarily-attached hair systems use double-sided sticky tape or clips to attach the hairpiece to your scalp and existing hair. You can remove and clean them any time you like but they can also be easily and unexpectedly removed, which can lead to embarrassing situations.
One thing that can surprise many potential buyers is the price. Although you can get a wig for a few hundred dollars, the more authentic-looking pieces cost a few thousand dollars and require regular maintenance costing a couple of hundred dollars a month. In addition, you need to buy at least two identical pieces, one to wear while the other is being maintained by your hair salon.
HAIR LOSS CONCEALERS
Hair loss concealers, also known as hair thickeners, are an alternative to hair systems for people who have some miniaturised fine hair left in their balding area. They are more comfortable to wear than wigs but they can never give a full head of hair to a completely bald person. They also seem to be a less expensive solution compared with hair systems.
There are three hair loss-concealing techniques that do the trick by: a) painting your scalp to match your hair colour, b) thickening your hair by coating and penetrating the hair and trapping moisture and volume-building proteins inside the hair shaft and, lastly, c) there are microfibers that cling to your hair like branches to the trunk of a tree, increasing the hair density. Microfiber-based, hair loss concealers can be typically applied in as little as 30 seconds, as opposed to a minimum of five minutes for hair-thickening concealers. However, microfibers are less water-resistant and it is quite difficult to apply them precisely and, therefore, they are not very good at creating an authentic-looking frontal hairline. Their biggest advantage is that they are unrecognizable in your hair, even with a very close inspection.
Hair thickeners, especially those that also colour your scalp, are extremely water-resistant and excellent for frontal hairlines but they take longer to apply. Their greatest weakness, in comparison to microfibers, is that in direct sunlight it can be visible to a sharp eye that the scalp has been painted. Some hair loss sufferers use a combination of two products simultaneously to overcome the weaknesses of individual products and to achieve the most authentic shade and appearance. Most often a combination of a hair thickener and a microfibrous concealer is used. The results of such combinations are often excellent even in people with very thin hair.
It can be concluded that wigs are more expensive and less comfortable than hair-loss concealers but they can cover a completely bald head, so they can also be used with burn patients and patients affected by alopecia areata, where concealers are of little help. Hair-loss concealers are suitable mainly for special occasions, when you want to look your best but many people use them permanently with good success.
About the Author
Visit the Dody’s website to learn more about different types of products used for concealing hair loss and for additional information on dealing with hair loss and other genetically-determined hair conditions such as premature gray hair and dandruff.
